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Normal physiology of insulin secretion and action. Selective Insulin Resistance in the Kidney. Horita S, Nakamura M, Suzuki M, Satoh N, Suzuki A, Seki G.
Sericin enhances the insulinâ€PI3K/AKT signalling pathway in the liver of a type 2 diabetes rat model. Song C, Liu D, Yang S, Cheng L, Xing E, Chen Z. Wushenziye Formula Improves Skeletal Muscle Insulin Resistance in Type 2 Diabetes Mellitus via PTP1B-IRS1-Akt-GLUT4 Signaling Pathway. There were also significant positive correlations between IRS-1 with PI3K and p38 MAPK levels (r = 0.375, p = 0.035 r = 0.552, p = 0.003 respectively) after the treatment.ĬONCLUSION: This study demonstrated significant positive correlations between IRS-1 with PI3K and p38 MAPK levels after puguntano leaf extract treatment of T2DM rats.
RESULTS: IRS-1, PI3K and p38 MAPK levels were significantly higher in the treatment group than in the control group. Data were analysed using the Wilcoxon test and Spearman’s correlation. IRS-1, PI3K and p38 MAPK levels were measured in skeletal muscle using sandwich ELISAs in control group after becoming T2DM and in the treatment group after 10 days of puguntano treatment. Puguntano leaf extract was administered to the treatment group once daily (200 mg/kg.bw) for 10 days. METHODS: A combination of high-fat diet-feeding (HFD) and multiple low dose intraperitoneal injections of streptozotocin was used to induced T2DM in 48 Wistar rats, which were then randomly divided into control and treatment groups (n = 24 per group). Puguntano, IRS-1, PI3K, p38 MAPK, T2DM AbstractīACKGROUND: Defects in post-receptor insulin signalling are the major cause of insulin resistance in type 2 diabetes mellitus (T2DM).ĪIM: This study aimed to investigate the correlations between insulin receptor substrate (IRS)-1 with phosphoinositide 3-kinase (PI3K) and p38 mitogen-activated protein kinase (MAPK) levels after puguntano ( Curanga fel-terrae ) leaf extract treatment in a rat model of T2DM. Adam Malik General Hospital, Medan, Indonesiaĭepartment of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesiaĭepartment of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesiaĭepartment of Biological Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, H.
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